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Excavatolide B

Chemical Structure : Excavatolide B

CAS No.: 205581-10-8

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Excavatolide B (ExcB)

Catalog No.: PC-24094Not For Human Use, Lab Use Only.

Excavatolide B (ExcB) is a marine diterpenoid of covalent STING inhibitor, covalently engages STING at its membrane-proximal Cys91, inhibits STING palmitoylation and signaling, inhibits IFN-β levels in culture supernatants of THP1 macrophages with IC50 of 12.1 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Excavatolide B (ExcB) is a marine diterpenoid of covalent STING inhibitor, covalently engages STING at its membrane-proximal Cys91, inhibits STING palmitoylation and signaling, inhibits IFN-β levels in culture supernatants of THP1 macrophages with IC50 of 12.1 uM.

Physicochemical Properties

M.Wt 592.64
Formula C30H40O12
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Butanoic acid, (2aS,3Z,6S,7R,7aR,8S,10S,11R,11aS,12S,12aS,13aR)-7,8,12-tris(acetyloxy)-1,2a,5,7,7a,8,9,10,11,11a,12,13a-dodecahydro-10-hydroxy-4,7a,11,13a-tetramethyl-1-oxo-6H-benzo[4,5]cyclodec[1,2-b]oxireno[c]furan-6-yl ester

References

1. Wan-Chi Hsiao, et al. Commun Chem. 2023 Jul 18;6(1):153.

2. Niu GH, et al. J Med Chem. 2025 Feb 27. doi: 10.1021/acs.jmedchem.4c02665.

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