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Chemical Structure : Exenatide
CAS No.: 141758-74-9
Catalog No.: PC-43538Not For Human Use, Lab Use Only.
Exenatide (Exendin-4) is a 39-aa peptide, highly potent, long-acting glucagon-like peptide-1 receptor (GLP-1) agonist with IC50 of 3.22 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 100 mg | Get quote |
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Exenatide (Exendin-4) is a 39-aa peptide, highly potent, long-acting glucagon-like peptide-1 receptor (GLP-1) agonist with IC50 of 3.22 nM.
Exenatide (Exendin-4) significantly increases NO production, endothelial NO synthase (eNOS) phosphorylation, and GTP cyclohydrolase 1 (GTPCH1) level in a dose-dependent manner in human umbilical vein endothelial cells.
Exenatide (Exendin-4) exhibits cytotoxic effects to MCF-7 breast cancer cells with IC50 of 5 uM。
Exenatide (Exendin-4) reduces serum glucose, insulin levels and calculated HOMA in ob/ob mice.
| M.Wt | 4186.572 | |
| Formula | C184H282N50O60S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL; H2O: 1.23 mg/mL (Need ultrasonic and warming) |
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| Chemical Name/SMILES |
L-Serinamide, L-histidylglycyl-L-a-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-a-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-a-glutamyl-L-a-glutamyl-L-a-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isole |
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1. Eng J, et al. J Biol Chem. 1992 Apr 15;267(11):7402-5.
2. Fidan-Yaylalı G, et al. Tumour Biol. 2016 Feb;37(2):2647-53.
3. Schepp W, et al. Eur J Pharmacol. 1994 Oct 14;269(2):183-91.
4. Doyle ME, et al. Regul Pept. 2003 Jul 15;114(2-3):153-8.
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