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Exenatide

Chemical Structure : Exenatide

CAS No.: 141758-74-9

Exenatide (Exendin-4)

Catalog No.: PC-43538Not For Human Use, Lab Use Only.

Exenatide (Exendin-4) is a 39-aa peptide, highly potent, long-acting glucagon-like peptide-1 receptor (GLP-1) agonist with IC50 of 3.22 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Exenatide (Exendin-4) is a 39-aa peptide, highly potent, long-acting glucagon-like peptide-1 receptor (GLP-1) agonist with IC50 of 3.22 nM.
Exenatide (Exendin-4) significantly increases NO production, endothelial NO synthase (eNOS) phosphorylation, and GTP cyclohydrolase 1 (GTPCH1) level in a dose-dependent manner in human umbilical vein endothelial cells.
Exenatide (Exendin-4) exhibits cytotoxic effects to MCF-7 breast cancer cells with IC50 of 5 uM。
Exenatide (Exendin-4) reduces serum glucose, insulin levels and calculated HOMA in ob/ob mice.

Physicochemical Properties

M.Wt 4186.572
Formula C184H282N50O60S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 32 mg/mL; H2O: 1.23 mg/mL (Need ultrasonic and warming)

Chemical Name/SMILES

L-Serinamide, L-histidylglycyl-L-a-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-a-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-a-glutamyl-L-a-glutamyl-L-a-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isole

References

1. Eng J, et al. J Biol Chem. 1992 Apr 15;267(11):7402-5.

2. Fidan-Yaylalı G, et al. Tumour Biol. 2016 Feb;37(2):2647-53.

3. Schepp W, et al. Eur J Pharmacol. 1994 Oct 14;269(2):183-91.

4. Doyle ME, et al. Regul Pept. 2003 Jul 15;114(2-3):153-8.

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