F-901318 (Olorofim) | Fungal DHODH inhibitor

Chemical Structure : F-901318

CAS No.: 1928707-56-5

F-901318 (Olorofim, F901318)

Catalog No.: PC-70224Not For Human Use, Lab Use Only.

F-901318 (Olorofim) is a novel antifungal agent that inhibits A. fumigatus DHODH with IC50 of 44 nM.

Packing	Price	Stock
5 mg	$278	In stock
10 mg	$458	In stock
25 mg	$788	In stock
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

F-901318 (Olorofim) is a novel antifungal agent that inhibits A. fumigatus DHODH with IC50 of 44 nM.
F-901318 (Olorofim) shows little inhibition of human DHODH (>100 uM).
F-901318 (Olorofim) displays excellent potency against a broad range of pathogenic filamentous and dimorphic fungi, including Penicillium spp., Coccidiodes immitis, H. capsulatum, Blastomyces dermatitidis, Fusarium spp., and the difficult-to-treat Scedosporium spp.

Physicochemical Properties

M.Wt	498.562
Formula	C28H27FN6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide

References

1. Oliver JD, et al. Proc Natl Acad Sci U S A. 2016 Oct 25. pii: 201608304.

2. Wiederhold NP, et al. J Antimicrob Chemother. 2017 Mar 15. doi: 10.1093/jac/dkx065.

3. Buil JB, et al. J Antimicrob Chemother. 2017 Jun 10. doi: 10.1093/jac/dkx177.

F-901318 (Olorofim, F901318)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.