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F0045(S)

Chemical Structure : F0045(S)

CAS No.: 2716077-17-5

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F0045(S) (F0045 S enantiomer)

Catalog No.: PC-38258Not For Human Use, Lab Use Only.

F0045(S) is a novel small-molecule fusion inhibitor of influenza A hemagglutinin (HA), shows EC50 of 0.5-1.9 uM against a panel of group 1 HAs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    F0045(S) is a novel small-molecule fusion inhibitor of influenza A hemagglutinin (HA), shows EC50 of 0.5-1.9 uM against a panel of group 1 HAs.
    Compound F0045 binds to pockets in the HA stem similar to bnAbs FI6v3 and CR9114, cyclic peptide P7, and small-molecule inhibitor JNJ4796.
    F0045(S) exhibited in vitro neutralization activity against multiple H1N1 and H5N1 strains.
    F0045(S) readily neutralized MDCK-SIAT1 infection by H1/Beijing (EC50=1.6 μM), H1/Cal04 (EC50 =3.9 μM), and H5 A/Vietnam/1203/2004 (EC50 =22.8 μM).

    Physicochemical Properties

    M.Wt 336.212
    Formula C17H15Cl2NO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-(2,4-dichlorophenyl)(2-phenylmorpholino)methanone

    References

    1. Yao Yao, et al. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18431-18438.

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