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F3406

Chemical Structure : F3406

CAS No.: 1115899-15-4

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F3406 (F-3406;VU0621623;F3406-2010)

Catalog No.: PC-60495Not For Human Use, Lab Use Only.

F3406 (VU0621623, F3406-2010) is a novel small-molecule arenaviruse inhibitor that exhibits strong anti-LCMV activity (IC50<1 uM) without cell toxicity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    F3406 (VU0621623, F3406-2010) is a novel small-molecule arenaviruse inhibitor that exhibits strong anti-LCMV activity (IC50<1 uM) without cell toxicity.
    F3406 inhibits LCMV cell entry by specifically interfering with the pH-dependent fusion in the endosome compartment that is mediated by LCMV glycoprotein GP2.
    F3406 inhibits LCMV multiplication with IC50 of 0.4, 0.7 and 0.9 uM in A549 BHK-21 and Vero cells, respectively.

    Physicochemical Properties

    M.Wt 449.477
    Formula C20H21F2N5O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3,5-difluorophenyl)-2-(5,7-dioxo-6-propyl-2-(pyrrolidin-1-yl)-6,7-dihydrothiazolo[4,5-d]pyrimidin-4(5H)-yl)acetamide

    References

    1. Ngo N, et al. J Virol. 2015 Nov;89(21):10924-33.

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