Chemical Structure : FAK PROTAC FC-11
CAS No.:
2271035-37-9
FAK PROTAC FC-11
Catalog No.: PC-25160Not For Human Use, Lab Use Only.
FAK PROTAC FC-11 is a potent and highly selective FAK PROTAC degrader with DC50 of 0.08 nM in PA-1 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FAK PROTAC FC-11 is a potent and highly selective FAK PROTAC degrader with DC50 of 0.08 nM in PA-1 cells.
FC-11 is based on a CRBN-mediated and proteasome-dependent mechanism.
FC-11 has DC50 as 310 pM in TM3, 80 pM in PA1, 330 pM in MDA-MB-436, 370 pM in LNCaP, and 40 pM in Ramos cells.
FC-11 exhibits rapid and highly efficient degradation of FAK in various cell lines with a DC50 at picomolar potencies for 8 h treatment.
Physicochemical Properties
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M.Wt
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949.92
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Formula
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C41H42F3N13O9S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1H-1,2,3-Triazole-4-carboxamide, 1-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-
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References
1. Gao H, et al. ACS Med Chem Lett. 2019 Oct 22;11(10):1855-1862.
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