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FAK inhibitor E2

Chemical Structure : FAK inhibitor E2

CAS No.: 2890814-94-3

FAK inhibitor E2

Catalog No.: PC-22876Not For Human Use, Lab Use Only.

FAK inhibitor E2 is a potent selective FAK inhibitor with IC50 of 3.58 nM, inhibits FAK downstream signaling cascades (e.g., Src and AKT), induces cytotoxic autophagy and inhibits ovarian cancer metastasis and growth.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FAK inhibitor E2 is a potent selective FAK inhibitor with IC50 of 3.58 nM, inhibits FAK downstream signaling cascades (e.g., Src and AKT), induces cytotoxic autophagy and inhibits ovarian cancer metastasis and growth.

Physicochemical Properties

M.Wt 567.69
Formula C32H37N7O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-((2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl) piperidin-1-yl) phenyl) amino)-7H-pyrrolo[2,3-d] pyrimidin-4-yl) oxy)-2,3-dihydro-1H-inden-1-one

References

1. Zhanzhan Feng, et al. Biochem Pharmacol. 2024 Aug 3:116461.

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