Chemical Structure : FASstatin
CAS No.:
1047504-12-0
FASstatin
(FASNi-8)
Catalog No.: PC-21673Not For Human Use, Lab Use Only.
FASstatin (FASNi-8) is an orally bioavailable small-molecule inhibitor of fatty acid synthase (FASN), directly binds FASN with SPR KD of 16 uM, potentiates TRIM56-mediated FASN ubiquitination.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FASstatin (FASNi-8) is an orally bioavailable small-molecule inhibitor of fatty acid synthase (FASN), directly binds FASN with SPR KD of 16 uM, potentiates TRIM56-mediated FASN ubiquitination.
FASstatin has higher suppressive effects on FASN protein expression, comparable FASN enzyme inhibition (FAS inhibitor C75), and higher efficacy insuppressing lipid droplet formation.
TRIM56 directly interacts with FASN and triggers its K48-linked ubiquitination-dependent degradation, FASstatin promotes TRIM56 dependent FASN ubiquitination.
FASstatin (50 mg/kg, p.o.) improved NAFLD and NASH pathologies in mice, did not affect body weight and the weight of liver, kidney, heart, lung and spleen.
Physicochemical Properties
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M.Wt
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534.64
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Formula
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C32H31FN6O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2-fluorophenyl)(4-(3-methyl-6-(4-methylbenzyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-1,4-diazepan-1-yl)methanone
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References
1. Suowen Xu, et al. J Clin Invest. 2024 Jan 11:e166149.
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