FC-8052 | HIV-1 Nef inhibitor | Probechem Biochemicals

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Chemical Structure : FC-8052

FC-8052 (FC8052)

Catalog No.: PC-38204Not For Human Use, Lab Use Only.

FC-8052 (FC8052) is a highly potent inhibitor of HIV-1 Nef-effector kinase, binds to recombinant Nef in vitro with Kd of 10 pM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FC-8052 (FC8052) is a highly potent inhibitor of HIV-1 Nef-effector kinase, binds to recombinant Nef in vitro with Kd of 10 pM.
FC-8052 inhibits Nef-dependent HIV-1 replication in PBMCs in the subnanomolar range.

Physicochemical Properties

M.Wt	540.036
Formula	C28H31ClFN5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-butyl 4-(1-(6-chloro-1H-benzo[d]imidazol-2-yl)-4-(4-fluorophenethyl)-5-hydroxy-1H-pyrazol-3-yl)piperidine-1-carboxylate

References

1. Staudt RP, et al. J Biol Chem. 2020 Oct 30;295(44):15158-15171.

2. Haibin Shi, et al. ACS Infect Dis. 2020 Feb 14;6(2):302-312.

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FC-8052 (FC8052)

Biological Activity

Physicochemical Properties

References

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