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FCCP

Chemical Structure : FCCP

CAS No.: 370-86-5

FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone)

Catalog No.: PC-42141Not For Human Use, Lab Use Only.

A potent ionophore and uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent ionophore and uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes; induces the complete disruption of cellular microtubules through a dual operation: increasing the intracellular pH by the disruption of the mitochondrial H+ gradient and decreasing the stability of microtubules by impairing the binding of microtubule-associated proteins.

Physicochemical Properties

M.Wt 254.1681
Formula C10H5F3N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 2.6 mg/mL

Chemical Name/SMILES

Propanedinitrile, 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-

References

1. Parker VH. Biochem J. 1965 Dec;97(3):658-62.

2. Benz R, et al. Biophys J. 1983 Mar;41(3):381-98.

3. Maro B, et al. EMBO J. 1982;1(11):1347-52.

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