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FCCP

Chemical Structure : FCCP

CAS No.: 370-86-5

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FCCP (Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone)

Catalog No.: PC-22179Not For Human Use, Lab Use Only.

FCCP is a small molecule mitochondrial uncoupler of oxidative phosphorylation (OXPHOS), induces activation of PINK1 leading to Parkin Ser65 phosphorylation, proton ionophore and mitophagy inducer.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FCCP is a small molecule mitochondrial uncoupler of oxidative phosphorylation (OXPHOS), induces activation of PINK1 leading to Parkin Ser65 phosphorylation, proton ionophore and mitophagy inducer.

Physicochemical Properties

M.Wt 254.17
Formula C10H5F3N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Carbonyl cyanide 4-(trifluoromethoxy) phenyl-hydrazone

References

1. Connop BP et al. J Neurochem. 1999 Apr;72(4):1457-65. 

2. Tanpradit N, et al. J Assist Reprod Genet. 2016 Dec;33(12):1621-1631.

3. Gautier CA, et al. Mol Neurodegener. 2012 May 25;7:22.

4. Gao F, et al. Aging Cell. 2020 Sep;19(9):e13211.

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