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FCPR03

Chemical Structure : FCPR03

CAS No.: 1917347-65-9

FCPR03 (FCPR 03)

Catalog No.: PC-62973Not For Human Use, Lab Use Only.

FCPR03 is a novel potent, selective PDE4 inhibitor with IC50 of 60, 31 and 47 nM for PDE4CAT (PDE4 catalytic domain), PDE4B1 and PDE4D7, respectively.

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Biological Activity

FCPR03 is a novel potent, selective PDE4 inhibitor with IC50 of 60, 31 and 47 nM for PDE4CAT (PDE4 catalytic domain), PDE4B1 and PDE4D7, respectively.
FCPR03 displays >2,000-fold selectivity over other PDEs.
FCPR03 effectively increases the production of cAMP, promotes CREB phosphorylation, and inhibits NF-κB activation both in vitro and in vivo.
FCPR03 displays anti-neuroinflammation potential, promising antidepressant-like effects in vivo.

Physicochemical Properties

M.Wt 299.318
Formula C15H19F2NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-N-isopropylbenzamide

References

1. Zou ZQ, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):67-77.

2. Zhou ZZ, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):135-146.

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