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Chemical Structure : FE 205030
Catalog No.: PC-72787Not For Human Use, Lab Use Only.
FE 205030 (FE205030) is a potent, selective peptidic CGRP antagonist with IC50 of 0.2 nM.
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FE 205030 (FE205030) is a potent, selective peptidic CGRP antagonist with IC50 of 0.2 nM.
FE 205030 displays>100,000 fold against hAM1R and >6363 fold against hAM2R tested in Human CGRP, AM1R and AM2R receptor cAMP assays.
FE 205030 inhibited CGRP-induced vasodilation in isolated human mesenteric resistance arteries in an ex vivo isometric myograph study; effectively blocked CGRP-induced vasodilation with a pA2 of 9.3.
FE 205030 is a first in class injectable fast acting selective and potent agent for the treatment of acute episodic migraine.
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1. Karthik Srinivasan, et al. J Pharm Sci. 2022 Jan;111(1):247-261.
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