FF-10501-01 |CAS:56973-26-3 Probechem Biochemicals

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Chemical Structure : FF-10501-01

FF-10501-01

Catalog No.: PC-61690Not For Human Use, Lab Use Only.

FF-10501-01 is a potent, selective and orally available IMPDH inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FF-10501-01 is a potent, selective and orally available IMPDH inhibitor.
FF-10501-01 effectively induces AML cell death and reduces AML peripheral blood cell proliferation (mean IC50=14.6 uM) by targeting guanine nucleotide biosynthesis regardless of HMA resistance status.

Physicochemical Properties

M.Wt	562.45
Formula	C4H5N3O2.3/4H2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Imidazole-4-carboxamide, 5-hydroxy-, hydrate (4:3)

References

1. Yang H, et al. Leuk Res. 2017 Aug;59:85-92.

2. Murase M, et al. Pharmacol Res Perspect. 2016 Jan 28;4(1):e00206.

3. Ichii M, et al. Leuk Lymphoma. 2017 Jul 21:1-12.

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FF-10501-01

Biological Activity

Physicochemical Properties

References

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