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FFN-206 dihydrochloride

Chemical Structure : FFN-206 dihydrochloride

CAS No.: 1883548-88-6

FFN-206 dihydrochloride (FFN206)

Catalog No.: PC-62373Not For Human Use, Lab Use Only.

FFN-206 is an excellent VMAT2 (vesicular monoamine transporter 2) substrate capable of detecting VMAT2 activity in intact cells using fluorescence microscopy, with subcellular localization to VMAT2-expressing acidic compartments without apparent labeling of other organelles.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FFN-206 is an excellent VMAT2 (vesicular monoamine transporter 2) substrate capable of detecting VMAT2 activity in intact cells using fluorescence microscopy, with subcellular localization to VMAT2-expressing acidic compartments without apparent labeling of other organelles; the apparent Km of FFN206 at VMAT2 was found to be 1.16±0.10 uM, similar to that of dopamine; an useful tool for optical examination of VMAT2 function in cell culture.

Physicochemical Properties

M.Wt 291.172
Formula C12H16Cl2N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(2-Aminoethyl)-7-(methylamino)-2H-1-benzopyran-2-one dihydrochloride

References

1. Hu G, et al. ACS Chem Biol. 2013 Sep 20;8(9):1947-54.

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