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FFN246

Chemical Structure : FFN246

CAS No.: 2210244-83-8 (free base)

FFN246 (FFN-246)

Catalog No.: PC-38583Not For Human Use, Lab Use Only.

FFN246 is a fluorescent, dual substrate of both SERT and VMAT2 with excitation and emission spectra 392/427 nm, demonstrates the applicability for labeling serotonergic neurons in mouse brain tissue through SERT-dependent accumulation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FFN246 is a fluorescent, dual substrate of both SERT and VMAT2 with excitation and emission spectra 392/427 nm, demonstrates the applicability for labeling serotonergic neurons in mouse brain tissue through SERT-dependent accumulation.
FFN246 could be used for direct examination of SERT activity and SERT inhibitors in 96-well cell culture assays, as well as specific labeling of serotonergic neurons of the dorsal raphe nucleus in the living tissue of acute mouse brain slices.
FFN246 effectively traces serotonin uptake and packaging in the soma of serotonergic neurons.

Physicochemical Properties

M.Wt 292.738
Formula C15H14ClFN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-(2-Aminoethyl)-1-fluoroacridin-9(10H)-one Hydrochloride

References

1. Adam Henke, et al. ACS Chem Neurosci. 2018 May 16;9(5):925-934.

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