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FGIN-1-27

Chemical Structure : FGIN-1-27

CAS No.: 142720-24-9

FGIN-1-27 (FGIN 1-27)

Catalog No.: PC-72081Not For Human Use, Lab Use Only.

FGIN-1-27 (FGIN 1-27) is an anxiolytic compound that acts as a selective agonist at the peripheral benzodiazepine receptor (TSPO) with Ki of 5 nM.

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Biological Activity

FGIN-1-27 (FGIN 1-27) is an anxiolytic compound that acts as a selective agonist at the peripheral benzodiazepine receptor (TSPO) with Ki of 5 nM.
FGIN-1-27 inhibited Th17 cell differentiation, significantly downregulated the expression of RORγt target genes, notably Il17a, Il17f, Il23r, Ltb4r1,Ccr6.
FGIN-1-27 protected mice against EAE, induced amino acid starvation response (AAR).
FGIN-1-27 produced anti-anxiety and anti-panic effects in non-mammalian models.

Physicochemical Properties

M.Wt 436.615
Formula C28H37FN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(2-(4-Fluorophenyl)-1H-indol-3-yl)-N,N-dihexylacetamide

References

1. Lima-Maximino MG, et al. Pharmacol Biochem Behav. 2018 Aug;171:66-73.

2. Singh A, et al. Sci Rep. 2020 Feb 28;10(1):3766.

3. Musicki B, et al. J Cell Physiol. 2021 Apr;236(4):3073-3082.

4. Rosenberg N, et al. Exp Clin Endocrinol Diabetes. 2018 Feb;126(2):77-84.

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