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Chemical Structure : FGIN-1-27
CAS No.: 142720-24-9
Catalog No.: PC-72081Not For Human Use, Lab Use Only.
FGIN-1-27 (FGIN 1-27) is an anxiolytic compound that acts as a selective agonist at the peripheral benzodiazepine receptor (TSPO) with Ki of 5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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FGIN-1-27 (FGIN 1-27) is an anxiolytic compound that acts as a selective agonist at the peripheral benzodiazepine receptor (TSPO) with Ki of 5 nM.
FGIN-1-27 inhibited Th17 cell differentiation, significantly downregulated the expression of RORγt target genes, notably Il17a, Il17f, Il23r, Ltb4r1,Ccr6.
FGIN-1-27 protected mice against EAE, induced amino acid starvation response (AAR).
FGIN-1-27 produced anti-anxiety and anti-panic effects in non-mammalian models.
| M.Wt | 436.615 | |
| Formula | C28H37FN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(2-(4-Fluorophenyl)-1H-indol-3-yl)-N,N-dihexylacetamide |
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1. Lima-Maximino MG, et al. Pharmacol Biochem Behav. 2018 Aug;171:66-73.
2. Singh A, et al. Sci Rep. 2020 Feb 28;10(1):3766.
3. Musicki B, et al. J Cell Physiol. 2021 Apr;236(4):3073-3082.
4. Rosenberg N, et al. Exp Clin Endocrinol Diabetes. 2018 Feb;126(2):77-84.
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