Chemical Structure : FHND9041
CAS No.:
2211116-92-4
FHND9041
(Adonertinib, FHND-9041)
Catalog No.: PC-27403Not For Human Use, Lab Use Only.
Adonertinib (FHND9041) is a third-generation, irreversible EGFR T790M mutation-selective inhibitor, selectively inhibitsphosphorylation of EGFR mutant kinase and the activation of its downstream key signaling molecules, Akt and Erk, thereby inhibiting the proliferation of tumor cells with EGFR T790M resistance or sensitive mutations and inducing apoptosis of tumor cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Adonertinib (FHND9041) is a third-generation, irreversible EGFR T790M mutation-selective inhibitor, selectively inhibitsphosphorylation of EGFR mutant kinase and the activation of its downstream key signaling molecules, Akt and Erk, thereby inhibiting the proliferation of tumor cells with EGFR T790M resistance or sensitive mutations and inducing apoptosis of tumor cells.
Physicochemical Properties
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M.Wt
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528.68
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Formula
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C30H32D3N7O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-Propenamide, N-[5-[[4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-pyrimidinyl]amino]-4-methoxy-2-[[2-(methylmethyl-d3-amino)ethyl]methylamino]phenyl]-
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References
1. Lu C, et al. BMC Pharmacol Toxicol. 2025 May 7;26(1):97.
2. Zeng L, et al. Lung Cancer. 2025 Sep;207:108684.
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