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FICZ

Chemical Structure : FICZ

CAS No.: 172922-91-7

FICZ (AhR agonist FICZ)

Catalog No.: PC-61627Not For Human Use, Lab Use Only.

FICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist with Kd of 70 pM.

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Biological Activity

FICZ (6-Formylindolo[3,2-b]carbazole) is a high affinity aryl hydrocarbon receptor (AhR) agonist with Kd of 70 pM.
FICZ induces transient expression of CYP1A1 in vitro, and potentiates NK cell IFN-γ production and cytolytic activity.
FICZ enhances NK cell control of tumors in an NK cell- and AhR-dependent manner in vivo;.
FICZ is an endogenous AhR ligand.

Physicochemical Properties

M.Wt 284.31
Formula C19H12N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5,11-dihydro-indolo[3,2-b]carbazole-6-carboxaldehyde

References

1. Rannug U, et al. Chem Biol. 1995 Dec;2(12):841-5.

2. Wincent E, et al. J Biol Chem. 2009 Jan 30;284(5):2690-6.

3. Shin JH, et al. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12391-6.

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