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Chemical Structure : FICZ
CAS No.: 172922-91-7
Catalog No.: PC-61627Not For Human Use, Lab Use Only.
FICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist with Kd of 70 pM.
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| 10 mg | $248 | In stock | |
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FICZ (6-Formylindolo[3,2-b]carbazole) is a high affinity aryl hydrocarbon receptor (AhR) agonist with Kd of 70 pM.
FICZ induces transient expression of CYP1A1 in vitro, and potentiates NK cell IFN-γ production and cytolytic activity.
FICZ enhances NK cell control of tumors in an NK cell- and AhR-dependent manner in vivo;.
FICZ is an endogenous AhR ligand.
| M.Wt | 284.31 | |
| Formula | C19H12N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5,11-dihydro-indolo[3,2-b]carbazole-6-carboxaldehyde |
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1. Rannug U, et al. Chem Biol. 1995 Dec;2(12):841-5.
2. Wincent E, et al. J Biol Chem. 2009 Jan 30;284(5):2690-6.
3. Shin JH, et al. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12391-6.
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