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Chemical Structure : FKGK18
CAS No.: 1071001-09-6
Catalog No.: PC-36138Not For Human Use, Lab Use Only.
FKGK18 (FKGK18) is a potent, selective inhibitor of iPLA2 (group VIA Ca2+-independent phospholipase A2) with IC50 of 50 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $378 | In stock | |
| 10 mg | $578 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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FKGK18 (FKGK-18) is a potent, selective inhibitor of iPLA2 (group VIA Ca2+-independent phospholipase A2) with IC50 of 50 nM.
FKGK18 displays 195 and >455 times more potent for GVIA iPLA(2) than for GIVA cPLA(2) and GV sPLA(2).
FKGK18 inhibits Ca2+-independent PLA2 activity in a concentration-dependent manner, similar to S-BEL, which preferentially inhibits cytosol-associated iPLA2β.
FKGK18 a valuable tool to explore the role of GVIA iPLA(2) in cells and in vivo models.
| M.Wt | 280.29 | |
| Formula | C16H15F3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,1,1-trifluoro-6-(naphthalen-2-yl)hexan-2-one |
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1. Kokotos G, et al. J Med Chem. 2010 May 13;53(9):3602-10.
2. Ali T, et al. PLoS One. 2013 Aug 20;8(8):e71748.
3. Bone RN, et al. Diabetes. 2015 Feb;64(2):541-54.
4. Dedaki C, et al. J Med Chem. 2019 Mar 12. doi: 10.1021/acs.jmedchem.8b01216.
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