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Chemical Structure : FLI-06
CAS No.: 313967-18-9
Catalog No.: PC-22605Not For Human Use, Lab Use Only.
FLI-06 is a pan-NOTCH receptor inhibitor, blocks Notch trafficking and processing, inhibits endogenous Notch signaling.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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FLI-06 is a pan-NOTCH receptor inhibitor, blocks Notch trafficking and processing, inhibits endogenous Notch signaling.
FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.
FLI-06 inhibits ER export at a pre-ERES step, potentially at the stage of cargo recruitment.
FLI-06 the first small molecule acting at such an early stage in secretory traffic.
| M.Wt | 438.52 | |
| Formula | C25H30N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate |
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1. Czerwonka A, et al. Biomed Pharmacother. 2024 Jun 20;177:116822.
2. Krämer A, et al. Nat Chem Biol. 2013 Nov;9(11):731-8.
3. Yonemura Y, et al. J Cell Sci. 2016 Oct 15;129(20):3868-3877.
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