Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : FLLL31
CAS No.: 52328-97-9
Catalog No.: PC-61669Not For Human Use, Lab Use Only.
FLLL31 (Tetramethylcurcumin) is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
FLLL31 (Tetramethylcurcumin) is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells.
FLLL31 induces apoptosis in pancreatic and breast cancer cell lines.
FLLL31 also inhibit colony formation in soft agar and cell invasion and exhibits synergy with Doxorubicin against breast cancer cells.
FLLL31 decreases STAT3 DNA binding activity and expression, and induces apoptosis in several cancer cell lines; also exhibits anti-inflammatory effects on macrophage activation, lymphocyte differentiation, and pro-inflammatory factor production.
| M.Wt | 424.49 | |
| Formula | C25H28O6 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione |
|
1. Lin L, et al. Cancer Res. 2010 Mar 15;70(6):2445-54.
2. Yuan S, et al. Int Immunopharmacol. 2014 Jul;21(1):128-36.
3. Holmer R, et al. BMC Cancer. 2015 Dec 16;15:975.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
