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Chemical Structure : FLT3-IN-5e
Catalog No.: PC-60368Not For Human Use, Lab Use Only.
FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM.
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FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM.
FLT3-IN-5e has high potentcy against mutant FLT3 D835H, D835V, D835Y, ITD-D835V, ITD-F691L, K663Q, N841I, and R834Q (Kd=0.36-82 nM).
FLT3-IN-5e shows weak (8-fold selectivity) activity for PDGFRB (28 nM) and the JAK1 JH2 domain (28 nM).
FLT3-IN-5e possesses growth inhibitory potencies against MOLM13 FLT3-ITD and MOLM13 FLT3-ITD/D835Y cells.
| M.Wt | 305.385 | |
| Formula | C18H19N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jarusiewicz JA, et al. ACS Omega. 2017 May 31;2(5):1985-2009.
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