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FLT3-IN-5e

Chemical Structure : FLT3-IN-5e

CAS No.: 2093038-25-4

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FLT3-IN-5e (FLT-3 inhibitor 5e)

Catalog No.: PC-60368Not For Human Use, Lab Use Only.

FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM.
    FLT3-IN-5e has high potentcy against mutant FLT3 D835H, D835V, D835Y, ITD-D835V, ITD-F691L, K663Q, N841I, and R834Q (Kd=0.36-82 nM).
    FLT3-IN-5e shows weak (8-fold selectivity) activity for PDGFRB (28 nM) and the JAK1 JH2 domain (28 nM).
    FLT3-IN-5e possesses growth inhibitory potencies against MOLM13 FLT3-ITD and MOLM13 FLT3-ITD/D835Y cells.

    Physicochemical Properties

    M.Wt 305.385
    Formula C18H19N5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N4-Isopropyl-N2-(3-(pyridin-3-yl)phenyl)pyrimidine-2,4-diamine

    References

    1. Jarusiewicz JA, et al. ACS Omega. 2017 May 31;2(5):1985-2009.

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