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Chemical Structure : FN1-8
Catalog No.: PC-61329Not For Human Use, Lab Use Only.
FN1-8 (Gli inhibitor FN1-8) is a synthetic small molecule that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity (at 15 uM).
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FN1-8 (Gli inhibitor FN1-8) is a synthetic small molecule that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity (at 15 uM).
FN1-8 inhibits non-canonical Gli activation and acts downstream of the canonical Hh pathway.
FN1-8 suppresses cancer cell proliferation in vitro and inhibits tumor growth in vivo.
| M.Wt | 447.538 | |
| Formula | C29H25N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bosco-Clément G, et al. Oncogene. 2014 Apr 17;33(16):2087-97.
2. He B, et al. US Patent No. 7714014. 2010
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