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FN1-8

Chemical Structure : FN1-8

CAS No.: 1419258-63-1

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FN1-8 (Gli inhibitor FN1-8)

Catalog No.: PC-61329Not For Human Use, Lab Use Only.

FN1-8 (Gli inhibitor FN1-8) is a synthetic small molecule that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity (at 15 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    FN1-8 (Gli inhibitor FN1-8) is a synthetic small molecule that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity (at 15 uM).
    FN1-8 inhibits non-canonical Gli activation and acts downstream of the canonical Hh pathway.
    FN1-8 suppresses cancer cell proliferation in vitro and inhibits tumor growth in vivo.

    Physicochemical Properties

    M.Wt 447.538
    Formula C29H25N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-hydroxybenzyl)-1,3,5-triphenyl-4,5-dihydro-1H-pyrazole-4-carboxamide

    References

    1. Bosco-Clément G, et al. Oncogene. 2014 Apr 17;33(16):2087-97.

    2. He B, et al. US Patent No. 7714014. 2010

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