Chemical Structure : FNDR-11124
CAS No.:
3056285-89-0
FNDR-11124
Catalog No.: PC-26221Not For Human Use, Lab Use Only.
FNDR-11124 is a potent broad-spectrum inhibitor of SARS-CoV-2, influenza, KFDV and representative flaviviruses and alphaviruses, targets viral RNA-dependent RNA polymerases (RdRp) across virus families.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FNDR-11124 is a potent broad-spectrum inhibitor of SARS-CoV-2, influenza, KFDV and representative flaviviruses and alphaviruses, targets viral RNA-dependent RNA polymerases (RdRp) across virus families.
FNDR-11124 showed dose-dependent antiviral activity against different SARS-CoV-2 variants, including delta, kappa, and England, with an EC50 ranging from 2.4 to 3.1 μM in the Vero E6 cell by the plaque assay.
FNDR-11124 demonstrated potent antiviral activity against SARS-CoV-2 and IAV/H1N1/PR8, with EC50 values of 1.1 μM and 0.9 μM, respectively.
FNDR-11124 exhibited potent inhibitory activity against hRSV and CHIKV, as well as against DENV-2, ZIKV and WNV, and KFDV.
FNDR-11124 blocks SARS-CoV-2 and IAV infections in animal studies.
Physicochemical Properties
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M.Wt
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330.34
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Formula
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C21H14O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-hydroxy-2-(4-phenoxyphenyl)-4H-chromen-4-one
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References
1. Rudramurthy GR, et al. Antiviral Res. 2026 Mar 2:106382. doi: 10.1016/j.antiviral.2026.106382.
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