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Chemical Structure : FOBISIN101
Catalog No.: PC-62030Not For Human Use, Lab Use Only.
FOBISIN101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively.
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FOBISIN101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively.
FOBISIN101 effectively blocks the ability of all seven 14-3-3 isoforms to stimulate exoenzyme S (ExoS) ADP-ribosyltransferase (IC50=6-19 uM in a functional assay).
FOBISIN101 also blocked the binding of 14-3-3 with Raf-1 and proline-rich AKT substrate, PRAS40.
| M.Wt | 461.209 | |
| Formula | C15H11N3Na3O8P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhao J, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16212-6.
2. Du Y, et al. J Biomol Screen. 2006 Apr;11(3):269-76.
3. Fu H, et al. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2320-4.
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