Catalog No.: PC-62030Not For Human Use, Lab Use Only.
FOBISIN101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively.
FOBISIN101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively.
FOBISIN101 effectively blocks the ability of all seven 14-3-3 isoforms to stimulate exoenzyme S (ExoS) ADP-ribosyltransferase (IC50=6-19 uM in a functional assay).
FOBISIN101 also blocked the binding of 14-3-3 with Raf-1 and proline-rich AKT substrate, PRAS40.
Physicochemical Properties
M.Wt
461.209
Formula
C15H11N3Na3O8P
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-[(2Z)-2-[4-formyl-6-methyl-5-oxo-3-(phosphonatooxymethyl)pyridin-2-ylidene]hydrazinyl]benzoate trisodium salt
References
1. Zhao J, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16212-6.
2. Du Y, et al. J Biomol Screen. 2006 Apr;11(3):269-76.
3. Fu H, et al. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2320-4.
