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FOXO1-IN-8

Chemical Structure : FOXO1-IN-8

CAS No.: 2678530-68-0

FOXO1-IN-8 (FOXO1 inhibitor 8)

Catalog No.: PC-60015Not For Human Use, Lab Use Only.

FOXO1-IN-8 (FOXO1 inhibitor 8) is a small molecule, selective FOXO1 inhibitor that inhibits FOXO-dependent glucose production devoid of lipogenic activity in hepatocytes.

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Biological Activity

FOXO1-IN-8 (FOXO1 inhibitor 8) is a small molecule, selective FOXO1 inhibitor that inhibits FOXO-dependent glucose production devoid of lipogenic activity in hepatocytes.
FOXO1 inhibitor 8 shows beneficial effects of FOXO1 inhibition on diabetic hyperglycemia by reducing hepatic glucose production.

Physicochemical Properties

M.Wt 243.27
Formula C12H13N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(2-(methylamino)pyrimidin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

References

1. Langlet F, et al. Cell. 2017 Nov 2;171(4):824-835.e18.

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