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FPFT-2216

Chemical Structure : FPFT-2216

CAS No.: 2367619-87-0

FPFT-2216 (FPFT2216)

Catalog No.: PC-20149Not For Human Use, Lab Use Only.

FPFT-2216 (FPFT2216) is a thalidomide derivative cereblon modulator that shows an inhibitory effect toward IKZF1 protein level, upregulates the production of IL-2 and degrades IKZF1 as well as CK-1α among ubiquitin–proteasomal degradative substrates of IMiDs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FPFT-2216 (FPFT2216) is a thalidomide derivative cereblon modulator that shows an inhibitory effect toward IKZF1 protein level, upregulates the production of IL-2 and degrades IKZF1 as well as CK-1α among ubiquitin–proteasomal degradative substrates of IMiDs.

Physicochemical Properties

M.Wt 262.29
Formula C11H10N4O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[4-(4-Methoxy-3-thienyl)-1H-1,2,3-triazol-1-yl]-2,6-piperidinedione

References

1. Mingxing Teng, et al. J Med Chem. 2022 Jan 13;65(1):747-756.

2. Gemechu Y,et al. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):11802-11807.

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