FPR1 agonist fMLF (NSC 350593) is a potent, selective formylpeptide receptor-1 (FPR1) agonist with EC50 of 80 nM in calcium flux, Ki of 38 nM.
fMLF activates mononuclear phagocytes to cellular activation, which is characterized by cellular polarization, chemotaxis, and release of proteolytic enzymes.
fMLF induces contractions in isolated guinea pig jejunum (EC50 = 11 nM), proximal colon (EC50 = 3.5 nM), and distal colon (EC50 = 2.2 nM).
fMLF induces neurotransmitter release from enteric motor neurons in vitro.
Physicochemical Properties
M.Wt
437.6
Formula
C21H31N3O5S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-formyl-L-methionyl-L-leucyl-L-phenylalanine
References
1. Lind S, et al. J Leukoc Biol. 2021 Jun;109(6):1105-1120.
2. Hu Y, et al. Chembiochem. 2014 Nov 3;15(16):2420-6.
3. Partida-Sánchez S, et al. J Immunol. 2004 Feb 1;172(3):1896-906.
4. Salamah MF, et al. J Thromb Haemost. 2019 Jul;17(7):1120-1133.
