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FPR2 agonist MR-39

Chemical Structure : FPR2 agonist MR-39

CAS No.: 2169267-60-9

FPR2 agonist MR-39 (MR-39)

Catalog No.: PC-20787Not For Human Use, Lab Use Only.

FPR2 agonist MR-39 is a ureidopropanamide agonist of formyl peptide receptor-2 (FPR2) with EC50 of 3.9 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FPR2 agonist MR-39 is a ureidopropanamide agonist of formyl peptide receptor-2 (FPR2) with EC50 of 3.9 uM.
MR-39 reduces IL-1β and TNF-α levels in LPS-stimulated microglial cells.
MR-39 elicits FPR2-mediated anti-inflammatory effects in rat microglia and also displays suitable pharmacokinetic characteristics.

Physicochemical Properties

M.Wt 508.95
Formula C27H23ClF2N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O=C(NCC1(C2=CC=C(F)C(Cl)=C2)CC1)[C@@H](NC(NC3=CC=C(F)C=C3)=O)CC4=CC=C(C#N)C=C4e

References

1. Ewa Trojan, et al. Cells. 2021 Jun 17;10(6):1524.

2. Stama M.L., et al. Eur. J. Med. Chem. 2017;141:703–720.

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