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FPR agonist Compound 43

Chemical Structure : FPR agonist Compound 43

CAS No.: 903895-98-7

FPR agonist Compound 43 (FPR agonist Cmpd43, Compound 43)

Catalog No.: PC-72086Not For Human Use, Lab Use Only.

FPR agonist Compound 43 is a potent agonist of human formyl-peptide-like 1 receptor (hFPRL1) with EC50 of 44 nM (hFPRL1-mediated Ca2+ mobilization).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FPR agonist Compound 43 is a potent agonist of human formyl-peptide-like 1 receptor (hFPRL1, FPR2) with EC50 of 44 nM (hFPRL1-mediated Ca2+ mobilization).
FPR agonist Compound 43 inhibited neutrophil (PMN) migration with IC50 of 1 uM.
FPR agonist Compound 43 showed a dose-dependent inhibition of ear swelling in mice following oral administration.

Physicochemical Properties

M.Wt 384.864
Formula C20H21ClN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(4-chlorophenyl)-3-(5-isopropyl-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)urea

References

1. Cheng Xue Qin, et al. Nat Commun. 2017 Feb 7;8:14232.

2. Agostino Cilibrizzi, et al. J Med Chem. 2009 Aug 27;52(16):5044-57.

3. Crocetti L, et al. Molecules. 2021 Oct 30;26(21):6583.

4. Roland W Bürli, et al. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3713-8.

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