Chemical Structure : FQI2-34
CAS No.:
2762499-38-5
FQI2-34
(FQI 2-34)
Catalog No.: PC-22044Not For Human Use, Lab Use Only.
FQI2-34 is a small molecule inhibitor of late SV40 factor (LSF, encoded by TFCP2) and β-catenin interaction, suppresses Wnt activity in CRC cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FQI2-34 is a small molecule inhibitor of late SV40 factor (LSF, encoded by TFCP2) and β-catenin interaction, specifically inhibits LSF DNA-binding, partner protein-binding, and transactivation activities, suppresses Wnt activity in CRC cells.
FQI2-34 at 1 μmol/L concentrations consistently reduced LSF–β-catenin interaction in different CRC cell lines.
FQI2-34 reduced colocalization of late SV40 factor (LSF) and β-catenin in colorectal cancer cell lines.
FQI2-34 (1-20 uM) inhibited Wnt activity in CRC cell lines irrespective of their Wnt status.
FQI2-34 suppressed β-catenin in both digitonin and nondigitonin fractions, decreased levels of cytosolic β-catenin in CRC cell lines.
FQI2-34 (5 mg/kg daily for 5 consecutive days each week). suppressed growth and Wnt targets in allogeneic colorectal cancer xenograft.
Physicochemical Properties
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M.Wt
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352.39
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Formula
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C20H20N2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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8-(4-(Dimethylamino)-2-Ethoxyphenyl)-[1,3]Dioxolo[4,5-g]Quinolin-6(5H)-One
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References
1. Lotfollahzadeh S, et al. Am J Pathol. 2022 Aug;192(8):1167-1185.
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