Chemical Structure : FR901464
CAS No.: 146478-72-0
Catalog No.: PC-62420Not For Human Use, Lab Use Only.
FR901464 is a potent antitumor natural product that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, inhibits cell cycle progression at G1 and G2/M phases.
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1 mg | $358 | In stock | |
2 mg | $558 | In stock | |
5 mg | $898 | In stock | |
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FR901464 is a potent antitumor natural product that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, inhibits cell cycle progression at G1 and G2/M phases.
M.Wt | 507.616 | |
Formula | C27H41NO8 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
2-Pentenamide, 4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadienyl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, (2Z,4S)- (9CI) |
1. Osman S, et al. Chemistry. 2011 Jan 17;17(3):895-904.
2. Albert BJ, et al. Mol Cancer Ther. 2009 Aug;8(8):2308-18.
3. Satoh T, et al. Sci Rep. 2016 Jun 10;6:27829.
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