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FR901464

Chemical Structure : FR901464

CAS No.: 146478-72-0

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FR901464 (FR-901464)

Catalog No.: PC-62420Not For Human Use, Lab Use Only.

FR901464 is a potent antitumor natural product that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, inhibits cell cycle progression at G1 and G2/M phases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FR901464 is a potent antitumor natural product that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, inhibits cell cycle progression at G1 and G2/M phases.

Physicochemical Properties

M.Wt 507.616
Formula C27H41NO8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Pentenamide, 4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadienyl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, (2Z,4S)- (9CI)

References

1. Osman S, et al. Chemistry. 2011 Jan 17;17(3):895-904.

2. Albert BJ, et al. Mol Cancer Ther. 2009 Aug;8(8):2308-18.

3. Satoh T, et al. Sci Rep. 2016 Jun 10;6:27829.

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