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FRAG-i

Chemical Structure : FRAG-i

CAS No.: 1401587-06-1

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FRAG-i (ZINC000079493999)

Catalog No.: PC-26856Not For Human Use, Lab Use Only.

FRAG-I is a small-molecule Drp1 inhibitor, binds the Drp1 GTPase domain with high affinity (Kd=732.4 nM), increases Drp1 thermal stability in recombinant and cellular assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FRAG-I is a small-molecule Drp1 inhibitor, binds the Drp1 GTPase domain with high affinity (Kd=732.4 nM), increases Drp1 thermal stability in recombinant and cellular assays.
FRAG-i selectively suppresses mitochondrial fission in A549 lung carcinoma cells while sparing the fused networks of non-cancerous BEAS-2B epithelial cells.
FRAG-i preserves mitochondrial membrane potential, ATP levels, and redox balance without cytotoxicity, and modulates Drp1, MiD49, and Mfn2 expression in a context-dependent manner.

Physicochemical Properties

M.Wt 384.41
Formula C17H16N6O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(3-(1H-indol-6-yl)-1,2,4-oxadiazol-5-yl)-N-(5-(methoxymethyl)-1,3,4-thiadiazol-2-yl)propanamide

References

1. Şeyma Ateşoğlu, et al. Mitochondrion. 2026 May 14:102162.

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