Chemical Structure : FRAX597
CAS No.:
1286739-19-2
FRAX597
(FRAX 597;FRAX-597)
Catalog No. : PC-44510Not For Human Use, Lab Use Only.
FRAX597 is a potent, selective ATP-competitive inhibitor of group I PAKs with IC50 of 8/13/19 nM for PAK1/2/3.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4451001
Biological Activity
FRAX597 is a potent, selective ATP-competitive inhibitor of group I PAKs with IC50 of 8/13/19 nM for PAK1/2/3 .
Physicochemical Properties
M.Wt
558.0969
Formula
C29H28ClN7OS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[2-chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-
References
1. Licciulli S, et al. J Biol Chem.
2. Chow HY, et al. Cancer Res.
3. Yeo D, et al. BMC Cancer.
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