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Chemical Structure : FRAX597
CAS No.: 1286739-19-2
Catalog No.: PC-44510Not For Human Use, Lab Use Only.
FRAX597 is a potent, selective ATP-competitive inhibitor of group I PAKs with IC50 of 8/13/19 nM for PAK1/2/3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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FRAX597 is a potent, selective ATP-competitive inhibitor of group I PAKs with IC50 of 8/13/19 nM for PAK1/2/3.
FRAX597 shows no effect on PAK4 (IC50>10 uM).
FRAX597 inhibits the proliferation of NF2-deficient schwannoma cells in culture.
FRAX597 displays potent anti-tumor activity in vivo, impairing schwannoma development in an orthotopic model of NF2.
| M.Wt | 558.0969 | |
| Formula | C29H28ClN7OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[2-chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]- |
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1. Licciulli S, et al. J Biol Chem. 2013 Oct 4;288(40):29105-14.
2. Chow HY, et al. Cancer Res. 2012 Nov 15;72(22):5966-75.
3. Yeo D, et al. BMC Cancer. 2016 Jan 16;16:24.
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