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Chemical Structure : FT234
Catalog No.: PC-72095Not For Human Use, Lab Use Only.
FT234 (FT-234) is a selective HDAC11 inhibitor.
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FT234 (FT-234) is a selective HDAC11 inhibitor.
FT234 demonstrated significant reduction in self-renewal stem-like SP cells with 2 uM FT234 or FT895, as well as the formation of vascular networks by SP cells at 5 uM compound treatment.
FT234 significantly decreased the mRNA of Sox2 as well as its target genes like HK2 and PDK2 in SPAdh cells.
FT234 compound inhibited the growth and viability by 60–80% in both A549 and H1650 cells at 5-10 uM, inhibited the viability of cancer cell lines A549 and H1650 ranged from 4.663–6.594 uM, reduced the viability of chemo-resistant cancer cells as well as chemo-insensitive CSCs.
FT234 selectively prevent growth of cancer cells in presence of cancer associated fibroblasts (CAFs).
| M.Wt | 338.144 | |
| Formula | C14H9Cl2N3O3 | |
| Appearance | Solid | |
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1. Namrata Bora-Singhal, et al. Sci Rep. 2020 Mar 13;10(1):4722.
2. Matthew W Martin, et al. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2143-2147.
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