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FT895

Chemical Structure : FT895

CAS No.: 2225728-57-2

FT895 (FT 895;FT-895)

Catalog No.: PC-35170Not For Human Use, Lab Use Only.

FT895 (FT-895) is a potent and selective inhibitor of HDAC11 with IC50 of 3 nM, displays no significant activity against HDAC1-10 (IC50>5 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FT895 (FT-895) is a potent and selective inhibitor of HDAC11 with IC50 of 3 nM, displays no significant activity against HDAC1-10 (IC50>5 uM).
FT895 displays promising cellular activity (IC50<20 nM) and pharmacokinetic properties.
FT895 is a useful tool to study the biology of HDAC11 and shows potential use as a therapeutic target for oncology and inflammation indications.

Physicochemical Properties

M.Wt 352.317
Formula C16H15F3N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-hydroxy-1,1-dimethyl-2-(5-(trifluoromethyl)pyrazin-2-yl)isoindoline-4-carboxamide

References

1. Martin MW, et al. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2143-2147.

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