FTI-2148 | FTase inhibitor | Probechem Biochemicals

Chemical Structure : FTI-2148

Catalog No.: PC-22630Not For Human Use, Lab Use Only.

FTI-2148 is a potent, selective farnesyltransferase (FTase) inhibitor with IC50 of 1.4 nM, >1000-fold selective over GGTase I.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FTI-2148 is a potent, selective farnesyltransferase (FTase) inhibitor with IC50 of 1.4 nM, >1000-fold selective over GGTase I.

M.Wt	452.57
Formula	C24H28N4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5-((((1H-imidazol-5-yl)methyl)amino)methyl)-2'-methyl-[1,1'-biphenyl]-2-carbonyl)-L-methionine

1. Sun J, et al. Cancer Res. 1999 Oct 1;59(19):4919-26.

2. Sun J, et al. Cancer Res. 2003 Dec 15;63(24):8922-9.

3. Carrico D, et al. Bioorg Med Chem. 2004 Dec 15;12(24):6517-26.