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Chemical Structure : FTI-2153
CAS No.: 344900-92-1
Catalog No.: PC-22629Not For Human Use, Lab Use Only.
FTI-2153 is the methylester prodrug of FTI-2148, a potent, selective farnesyltransferase (FTase) inhibitor with IC50 of 1.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $378 | In stock | |
| 10 mg | $578 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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FTI-2153 is the methylester prodrug of FTI-2148, a potent, selective farnesyltransferase (FTase) inhibitor with IC50 of 1.4 nM.
FTI-2153 is >3000-fold more potent at inhibiting H-Ras (IC50, 10 nM) than Rap1A processing.
FTI-2153 is highly effective at suppressing oncogenic H-Ras constitutive activation of mitogen-activated protein kinase and human tumor growth in soft agar.
FTI-2153 blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.
| M.Wt | 466.60 | |
| Formula | C25H30N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
L-Methionine, N-[[5-[[(1H-imidazol-5-ylmethyl)amino]methyl]-2′-methyl[1,1′-biphenyl]-2-yl]carbonyl]-, methyl ester |
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1. Sun J, et al. Cancer Res. 1999 Oct 1;59(19):4919-26.
2. Crespo NC, et al. J Biol Chem. 2001 May 11;276(19):16161-7.
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