Chemical Structure : FTI-277
CAS No.:
170006-73-2
FTI-277
(FTI 277)
Catalog No. : PC-44766Not For Human Use, Lab Use Only.
FTI-277 is a peptide mimetic of the C-terminal Cys-Val-Ile-Met of K-Ras4B that potently inhibits FTase (Farnesyltransferase) with IC50 of 0.5 nM.
Packing Price Stock Quantity 2 mg $68 In stock 0 1 2 3 4 5 5 mg $108 In stock 0 1 2 3 4 5 10 mg $178 In stock 0 1 2 3 4 5 25 mg $278 In stock 0 1 2 3 4 5 50 mg $458 In stock 0 1 2 3 4 5 100 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4476601
Biological Activity
FTI-277 is a peptide mimetic of the C-terminal Cys-Val-Ile-Met of K-Ras4B that potently inhibits FTase (Farnesyltransferase) with IC50 of 0.5 nM.
Physicochemical Properties
M.Wt
447.614
Formula
C22H29N3O3S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
L-Methionine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester
References
1. Lerner EC, et al. J Biol Chem
2. Bernhard EJ, et al. Cancer Res
3. Bolick SC, et al. Leukemia
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