Catalog No.: PC-44767Not For Human Use, Lab Use Only.
FTI-277 hydrochloride is a peptide mimetic of the C-terminal Cys-Val-Ile-Met of K-Ras4B that potently inhibits FTase (Farnesyltransferase) with IC50 of 0.5 nM.
FTI-277 hydrochloride is a peptide mimetic of the C-terminal Cys-Val-Ile-Met of K-Ras4B that potently inhibits FTase (Farnesyltransferase) with IC50 of 0.5 nM.
FTI-277 hydrochloride highly selective for FTase over GGTase I (IC50 = 50 nM).
FTI-277 hydrochloride extremely potent (IC50=100 nM) at inhibiting H-Ras in whole cells.
FTI-277 hydrochloride blocks Ras oncogenic signaling by accumulating inactive Ras/Raf complexes in the cytoplasm.
