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Chemical Structure : FZU-00,004
Catalog No.: PC-22991Not For Human Use, Lab Use Only.
FZU-00,004 is a small molecule inhibitor of Krüppel-like Factor 5 (KLF5), inhibits KLF5 expression, significantly suppresses TNBC tumor cell growth in vitro and in vivo.
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FZU-00,004 is a small molecule inhibitor of Krüppel-like Factor 5 (KLF5), inhibits KLF5 expression, significantly suppresses TNBC tumor cell growth in vitro and in vivo.
FZU-00,004 inhibits anticancer effects against SUM149PT and HCC1937 with IC50 of 3.6 and 7.9 uM, respectively, induces G1/S cell cycle arrest.
FZU-00,004 inhibits KLF5 expression and induces the cleavage of PARP.
FZU-00,004 (1.0 mg/d) suppresses growth of TNBC UM1 patient-derived xenograft (PDX) tumors in nude mice.
| M.Wt | 588.57 | |
| Formula | C35H35Cl2NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Qi Wu, et al. Theranostics. 2023 Feb 21;13(4):1381-1400.
2. Yuqi Lin, et al. Eur J Med Chem. 2018 Feb 25:146:354-367.
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