Factor XIIa inhibitor F38

Chemical Structure : Factor XIIa inhibitor F38

Catalog No.: PC-26827Not For Human Use, Lab Use Only.

Factor XIIa inhibitor F38 is highly potent, selective and irreversible inhibitor of Factor XIIa (FXIIa) with IC50 of 2 nM, exhibits potent anticoagulant activity (EC1.5X=11 uM) and anti-inflammatory effects.

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Biological Activity

Physicochemical Properties

M.Wt	554.66
Formula	C30H34N8O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-(5-amino-3-(quinoxalin-2-yl)-1H-1,2,4-triazol-1-yl)(6-(3-(isopropyl(methyl)amino)pyrrolidin-1-yl)-2H,4H-spiro[benzo[b][1,4]dioxepine-3,1'-cyclopropan]-9-yl)methanone

References

1. Geng L, et al. J Med Chem. 2026 May 14. doi: 10.1021/acs.jmedchem.6c01243.

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Factor XIIa inhibitor F38

Biological Activity

Physicochemical Properties

References

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