Chemical Structure : Fam20C inhibitor 5k
CAS No.:
3059559-33-7
Fam20C inhibitor 5k
Catalog No.: PC-23588Not For Human Use, Lab Use Only.
Fam20C inhibitor 5k is a potent small-molecule Fam20C inhibitor with IC50 of 2.1 uM, showspotent anti-proliferative activity against MDA-MB-231 and BT-549 cells with IC50 values of 11.8 uM and 9.7 uM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Fam20C inhibitor 5k is a potent small-molecule Fam20C inhibitor with IC50 of 2.1 uM, showspotent anti-proliferative activity against MDA-MB-231 and BT-549 cells with IC50 values of 11.8 uM and 9.7 uM, respectively.
Compound 5k inhibits proliferation and induces apoptosis in TNBC cells.
Compound 5k inhibits the migration of MDA-MB-231 and BT-549 cells, inhibits the expression of epithelial-mesenchymal transition (EMT) markers.
Compound 5k (10-40 mg/kg) suppresses tumor growth in xenograft tumor nude mouse model of MDA-MB-231 cells, with no noticeable adverse effects.
Physicochemical Properties
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M.Wt
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555.92
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Formula
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C26H24BrClN4OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((1-(3-Bromobenzyl)-1H-benzo[d]imidazol-2-yl)thio)-1-(4-(4-chlorophenyl)piperazin-1-yl)ethan-1-one
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References
1. Lu Y, et al. Int J Biol Macromol. 2024 Dec 6:138398.
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