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Fangchinoline

Chemical Structure : Fangchinoline

CAS No.: 436-77-1

Fangchinoline

Catalog No.: PC-27150Not For Human Use, Lab Use Only.

Fangchinoline is a natural bisbenzylisoquinoline alkaloid isolated from Stephania tetrandra whtinin extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis, inhibits HIV-1 replication by impairing gp160 proteolytic processing, suppresses FAK-mediated signaling pathway in cancer cells which highly expressed FAK, enhances antigen cross-presentation in a DNGR-1 (CLEC9A)-dependent manner.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Fangchinoline is a natural bisbenzylisoquinoline alkaloid isolated from Stephania tetrandra whtinin extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis, inhibits HIV-1 replication by impairing gp160 proteolytic processing, suppresses FAK-mediated signaling pathway in cancer cells which highly expressed FAK, enhances antigen cross-presentation in a DNGR-1 (CLEC9A)-dependent manner.

Physicochemical Properties

M.Wt 608.74
Formula C37H40N2O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(11S,31S)-16,36,54-Trimethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphan-37-ol

References

1. Liao Y, et al. Adv Sci (Weinh). 2026 Jun 11:e76043.

2. Wan Z, et al. PLoS One. 2012;7(6):e39225.

3. Guo B, et al. J Drug Target. 2015 Apr;23(3):266-74.

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