Fasnall

Chemical Structure : Fasnall

CAS No.: 929978-58-5

Catalog No.: PC-20378Not For Human Use, Lab Use Only.

Fasnall is a potent, selective fatty acid synthase (FASN) inhibitor with IC50 of 3.71 uM for purified human FASN isolated from the BT474 cell line.

Packing	Price	Stock
5 mg	$138	In stock
10 mg	$218	In stock
25 mg	$368	In stock
50 mg	$558	In stock
100 mg		Get quote

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Biological Activity

Fasnall is a potent, selective fatty acid synthase (FASN) inhibitor with IC50 of 3.71 uM for purified human FASN isolated from the BT474 cell line.
Fasnall potently blocked both acetate and glucose incorporation into total lipids, with IC50 values of 147 and 213 nM, respectively, in HepG2 cells.
Fasnall inhibits the incorporation of tritiated acetat in BT474 cells with IC50 of 5.84 uM.
Fasnall does not inhibit ACC (acetyl-CoA carboxylase), Hsp90, Hsp70, TRAP-1, DAP kinase 3, IRAK 2, AMPK α and γ subunits, NEK9, dengue nonstructural protein 5, malarial kinase PfPK9, and HSF-1.
Fasnall inhibited the proliferation of aggressive breast cancer cell lines, with profound changes in cellular lipid profiles, sharply increasing ceramides, diacylglycerols, and unsaturated fatty acids.
Fasnall (5-15 mg/kg) showed potent anti-tumor activity in the MMTV-Neu model of HER2+ breast cancer.

Physicochemical Properties

M.Wt	338.47
Formula	C19H22N4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]-thieno[2,3-d]pyrimidin-4-amine

References

1. Alwarawrah Y, et al. Cell Chem Biol. 2016 Jun 23;23(6):678-88.

2. Gifford GK, et al. Leuk Lymphoma. 2020 Aug;61(8):1810-1822.

Fasnall

Biological Activity

Physicochemical Properties

References

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