Fasudil (AT-877, HA-1077) | ROCK inhibitor

Chemical Structure : Fasudil

Fasudil (AT-877, HA-1077, AT877; HA1077)

Catalog No.: PC-42541Not For Human Use, Lab Use Only.

Fasudil (AT-877, HA-1077) is a potent and selective inhibitor of Rho kinase (ROCK) with Ki of 0.33 uM (ROCK1).

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Biological Activity

Fasudil (AT-877, HA-1077) is a potent and selective inhibitor of Rho kinase (ROCK) with Ki of 0.33 uM (ROCK1).
Fasudil (AT-877, HA-1077) displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively.
Fasudil (AT-877, HA-1077) exhibits vasodilator actions by inhibition of 5-hydroxytryptamine, noradrenaline, histamine, angiotensin, and dopamine induced spiral strips contraction.

Physicochemical Properties

M.Wt	291.3687
Formula	C14H17N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-

References

1. Uehata M, et al. Nature. 1997 Oct 30;389(6654):990-4.

2. Asano T, et al. J Pharmacol Exp Ther. 1987 Jun;241(3):1033-40.

3. Asano T, et al. Br J Pharmacol. 1989 Dec;98(4):1091-100.

Fasudil (AT-877, HA-1077, AT877; HA1077)

Biological Activity

Physicochemical Properties

References

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