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Chemical Structure : Fasudil
Catalog No.: PC-42541Not For Human Use, Lab Use Only.
Fasudil (AT-877, HA-1077) is a potent and selective inhibitor of Rho kinase (ROCK) with Ki of 0.33 uM (ROCK1).
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Fasudil (AT-877, HA-1077) is a potent and selective inhibitor of Rho kinase (ROCK) with Ki of 0.33 uM (ROCK1).
Fasudil (AT-877, HA-1077) displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively.
Fasudil (AT-877, HA-1077) exhibits vasodilator actions by inhibition of 5-hydroxytryptamine, noradrenaline, histamine, angiotensin, and dopamine induced spiral strips contraction.
| M.Wt | 291.3687 | |
| Formula | C14H17N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Uehata M, et al. Nature. 1997 Oct 30;389(6654):990-4.
2. Asano T, et al. J Pharmacol Exp Ther. 1987 Jun;241(3):1033-40.
3. Asano T, et al. Br J Pharmacol. 1989 Dec;98(4):1091-100.
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