Fevipiprant | CRTH2 inhibitor | Probechem Biochemicals

Chemical Structure : Fevipiprant

CAS No.: 872365-14-5

Fevipiprant (NVP-QAW039, QAW039)

Catalog No.: PC-45075Not For Human Use, Lab Use Only.

Fevipiprant (NVP-QAW039, QAW-039) is a potent, selective, slowly dissociating CRTh2 antagonist with Kd of 1.14 nM.

Packing	Price	Stock
10 mg	$98	In stock
25 mg	$158	In stock
50 mg	$258	In stock
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Fevipiprant (NVP-QAW039, QAW-039) is a potent, selective, slowly dissociating CRTh2 antagonist with Kd of 1.14 nM.
NVP-QAW039 shows a half-life of 14.4 minutes, >7-fold slower than AZD-1981.
NVP-QAW039 inhibits PGD2-stimulated human eosinophil shape change, retains its potency in the whole-blood shape-change assay relative to the isolated shape change assays.
NVP-QAW039 also is a potent inhibitor of PGD2-induced cytokine release in human Th2 cells.

Physicochemical Properties

M.Wt	426.4095
Formula	C19H17F3N2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, 2-methyl-1-[[4-(methylsulfonyl)-2-(trifluoromethyl)phenyl]methyl]-

References

1. Sykes DA, et al. Mol Pharmacol. 2016 May;89(5):593-605.

2. Sandham DA, et al. ACS Med Chem Lett. 2017 Apr 25;8(5):582-586.

3. Bateman ED, et al. Eur Respir J. 2017 Aug 24;50(2). pii: 1700670.

Fevipiprant (NVP-QAW039, QAW039)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.