Chemical Structure : Fezolinetant
CAS No.:
1629229-37-3
Fezolinetant
(ESN-364, ESN364)
Catalog No. : PC-70195Not For Human Use, Lab Use Only.
Fezolinetant (ESN-364) is a potent, selective, orally active neurokinin-3 receptor (NK3R) antagonist with pIC50/pKi of 7.7/7.6.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-7019501
Biological Activity
Fezolinetant (ESN-364) is a potent, selective, orally active neurokinin-3 receptor (NK3R) antagonist with pIC50/pKi of 7.7/7.6.
Physicochemical Properties
M.Wt
358.3954
Formula
C16H15FN6OS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
[(8R)-5,6-Dihydro-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl](4-fluorophenyl)methanone
References
1. Hoveyda HR, et al. ACS Med Chem Lett.
2. Fraser GL, et al. Endocrinology.
3. Fraser GL, et al. J Clin Endocrinol Metab.
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