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Chemical Structure : FiVe1
CAS No.: 932359-76-7
Catalog No.: PC-63320Not For Human Use, Lab Use Only.
FiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase, causes mitotic catastrophe, multinucleation, and the loss of stemness in cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $388 | In stock | |
| 10 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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FiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase, causes mitotic catastrophe, multinucleation, and the loss of stemness in cancer cells.
FiVe1 selectively and irreversibly inhibits the growth of mesenchymally transformed breast cancer cells ( FOXC2-HMLER cells IC50=234 nM) and soft tissue sarcomas of diverse histological subtypes.
| M.Wt | 359.254 | |
| Formula | C18H16Cl2N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
8-chloro-4-(4-(3-chlorophenyl)piperazin-1-yl)cinnoline |
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1. Bollong MJ, et al. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912.
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