Catalog No.: PC-20033Not For Human Use, Lab Use Only.
Ficonalkib (SY-3505) is a potent, selective, 3rd-generation anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 1.3 nM and 1.5 nM for WT ALK, and F1174L mutant.
Ficonalkib (SY-3505) is a potent, selective, 3rd-generation anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 1.3 nM and 1.5 nM for WT ALK, and F1174L mutant.
Ficonalkib (SY-3505) exhibits potent inhibition against both wild-type ALK and a diverse spectrum of mutants resistant to 1st- and 2nd-gen ALK TKI, including L1196M, G1202R, F1174L, G1269S, and R1275Q (IC50s=0.8-2.7 nM).
Ficonalkib (SY-3505) exhibits high kinase selectivity and has very weak inhibition on tropomyosin receptor kinase (TRK) family members (TRKA-C).
