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Chemical Structure : Ficonalkib
CAS No.: 2233574-95-1
Catalog No.: PC-20033Not For Human Use, Lab Use Only.
Ficonalkib (SY-3505) is a potent, selective, 3rd-generation anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 1.3 nM and 1.5 nM for WT ALK, and F1174L mutant.
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|---|---|---|---|
| 1 mg | $248 | In stock | |
| 5 mg | $598 | In stock | |
| 10 mg | $898 | In stock | |
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| 100 mg | Get quote |
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Ficonalkib (SY-3505) is a potent, selective, 3rd-generation anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 1.3 nM and 1.5 nM for WT ALK, and F1174L mutant.
Ficonalkib (SY-3505) exhibits potent inhibition against both wild-type ALK and a diverse spectrum of mutants resistant to 1st- and 2nd-gen ALK TKI, including L1196M, G1202R, F1174L, G1269S, and R1275Q (IC50s=0.8-2.7 nM).
Ficonalkib (SY-3505) exhibits high kinase selectivity and has very weak inhibition on tropomyosin receptor kinase (TRK) family members (TRKA-C).
| M.Wt | 565.74 | |
| Formula | C29H39N7O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N2-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)-N4-(2-(isopropylsulfonyl)phenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diamine |
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1. Patent WO2018127184 A1.
2. Yuankai Shi, et al. J Thorac Oncol. 2024 Jun;19(6):898-911.
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